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20 Surgical excision of HS is occasionally used with silicone gel sheeting or surgical taping The best way to splint the scars is by surgical closure with intradermal sutures for a minimum of 6 weeks and up to 6 months if the tension is substantial W-plasty and Z-plasty techniques, while useful in treating burn scars, are not optimal for immature HS20 However, surgery also involves the risk of leaving another scar Other treatment options include the antimetabolite 5-FU, which can be used as an intralesional injection for HS, either alone or with laser treatment It targets the fast-proliferating and metabolizing broblasts in dermal wounds responsible for extra collagen production8 Injections of interferon , , and can increase collagen breakdown but can also be painful enough to necessitate anesthesia.

Mutualism. Both species benefit ( ). Commensalism. One species benefits ( ) and one species is fairly unaffected (~). Parasitism. One species benefits ( ) and one species is harmed ( ). A related mechanism of passive competition is camouflage and mimicry. Endemic species, naturally occurring in only one area or region, are unique to that specific region. The total area in which a plant, animal, insect, or other organism may travel in its lifetime is considered its range. The first colonizers to a site (e.g., moss or lichens) are called pioneer species. A species around which an entire ecosystem is dependent is known as a keystone or foundational species. Endangered species are those species threatened with extinction (like the Florida panther and California condor). A species that is no longer living, anywhere on Earth, is said to be extinct. The area in which an animal, plant, or microorganism lives and finds nutrients, water, sunlight, shelter, living space, and other essentials is called its habitat. Wetlands are low, soggy places where land is constantly or seasonally soaked, or even partly underwater. An ecological region that has lost more than 70% of its original habitat is known as an environmental hotspot.

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R5,R6,R10 10 k ohm, / w, 4 5% resistor R7,R8,R9,R12,R21 33 k ohm, 14w, 5% resistor / R11,R16 1 k ohm, / w, 4 5% resistor R13,R20 22 k ohm, 14w, / 5% resistor R14,R15,R18,R19 47 k ohm, 14w, 5% resistor / R17 50 k ohm pot R22 2.2k ohm, 14w, / 5% resistor C1,C2,C3,C4,C5,C6 .1 F, 35 volt disk capacitor C11,C12,C13,C14 .1 F, 35 volt disk capacitor C8,C9 1 F tantalum, 35 volt electrolytic capacitor C10 .01 F, 35 volt disk capacitor C7 D1 .05 F, 35 volt disk capacitor Zener diode LTC1063 IC

20 Bleomycin injections can be useful for HS resistant to intralesional corticosteroids, and in some cases have caused signi cant or complete scar attening Cryosurgery, via spray or intralesional needle, has also been shown to decrease the volume of the scar, and improve pain, itching, hardness, and scar color8 HS can also be successfully treated with the pulsed dye laser (PDL) Operating on the principles of selective photothermolysis,21 the PDL was designed speci cally to treat vascular lesions HS treatment parameters include a wavelength of 595 nm, uences between 6 to 10 J/cm2, pulse durations of 450 s, and spot sizes between 2 to 10 mm1,22,23 PDL treatment is analogous to snapping a rubber band on the patient, but it is usually endured with only mild.

Example 8.5 Figure 8.12 displays results of the carrier smoothed code op eration. The top graph displays w w n (solid) and C (dashed). The estimate of the constant C is signi cantly smoother than the instantaneous w n . value of w The variable r is the pseudorange plus the ionosphere and common mode errors. In particular, for the i-th SV, r contains the range R(p, pi ) and the receiver clock error which are large and change rapidly relative to the other

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where the slope@is calledan incrcnzent Junction.Accordingto this equation,the slopeestimate of @is usedto extrapolate liom an old value -yrto a new value y;11 over a distance /2.This fornrula can be appliedstep by stepto traceout the trajectoryof the solution into ntethods the future. Suchapproaches calledute-ste1t are because value of the increment the point i. They are also refelred to as Rwrgefunction is basedon information at a single who first discussed them in the early Kutta ntethodsafter the two appliedmathematicians 1900s.Another class of rnethodscalled multistepmethodsuse information from several previous points as the basisfor extrapolating a new value. We will describemultistep to rnethods briefly in Chap.21. All one-step methodscan be expressed the generalform of Eq. (20.4),with the only in differencebeing the mannerin which the slopeis estimated. The sirnplestapproachis to the use the differentialequationto estimate slopein the fbrm of the first derivativeat /;. ln other words, the slopeat the beginningof the interval is taken as an approximationof the averageslope over the whole interval.This approach, called Euler's method,is discussed next. This is followed by other one-stepmethodsthat employ alternativeslope estimates predictions. that result in more accurate

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