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In most computers, the memory is volatile This means that it requires a source of power to be maintained If you switch the computer off, or if there s a power failure, you ll lose all the data in the memory This problem can be avoided if the memory chips are supplied with power continuously Some machines have rechargeable memory backup batteries that keep memory data intact for short periods if there is a power failure In contrast to memory, the data on magnetic disks, or on optical media, will stay put when the power is removed When you re working on a file, it is wise to store the file every few minutes on the hard drive and/or diskette That way, in the rare event a power failure does occur, you won t lose much work

Drugs that act primarily as CNS stimulants have a relatively limited therapeutic use but assume clinical importance for other reasons Some members of this group, eg, the amphetamines, are much abused, and others are not infrequent causes of poisoning Amphetamines (Benzedrine, Adderall) These drugs and dextroamphetamine, its D-isomer, are powerful analeptics (CNS stimulants) and in addition have signi cant hypertensive, respiratorystimulant, and appetite-depressant effects They are effective in the management of narcolepsy but have been much more widely and sometimes indiscriminately used for the control of obesity, the abolition of fatigue, and the treatment of hyperactivity in children Undoubtedly, they are able to reverse fatigue, postpone the need for sleep, and elevate mood, but these effects are not entirely predictable, and the user must pay for the period of wakefulness with even greater fatigue and often with depression that may follow The intravenous use of a high dose of amphetamine produces an immediate feeling of ecstasy, the ash Because of the popularity of the amphetamines and the ease with which they can be procured, instances of acute and chronic intoxication are observed frequently The toxic signs are essentially an exaggeration of the analeptic effects restlessness, excessive speech and motor activity, tremor, and insomnia Severe intoxication may give rise to hallucinations, delusions, and changes in affect and thought processes a state that may be indistinguishable from paranoid schizophrenia An amphetamine associated vasculitis and intracerebral and subarachnoid hemorrhage are well-recognized but rare complications of chronic intoxication (Harrington et al), and they may occur after acute use as well Similar cerebrovascular complications may appear with sympathomimetic agents contained in over-the-counter cold medications and in dieting aids Phenylpropanolamine has been implicated most often, but ephedrine and similar agents rarely have the same effects and induce a vasculopathy The pathogenesis of the vascular lesion is unknown (both vasospasm and arteritis have been reported), and the same state occurs with cocaine, as described below Chronic use of amphetamines can lead to a high degree of tolerance and psychologic dependence Withdrawal of the drug after sustained oral or intravenous use is regularly followed by a period of prolonged sleep (a disproportionate amount of which is REM sleep), from which the patient awakens with a ravenous appetite, muscle pains, and feelings of profound fatigue and depres-.

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The conventional use of cocaine as a local anesthetic has for many years been overshadowed by its illicit and widespread use as a stimulant and mood elevator Originally, cocaine was sold as a white, lactose-adulterated powder that was administered intranasally ( snorted ); less often, it was smoked or injected intravenously or intramuscularly Since 1985 there has been an alarming escalation in the use of cocaine, mainly because a relatively pure and inexpensive form of the free alkaloid base ( crack ) became readily available at that time This form of cocaine is heat-stable and therefore suitable for smoking According to the National Household Survey on Drug Abuse, there are an estimated 600,000 frequent cocaine users in the United States (Frequent use was arbitrarily de ned as use on 51 or more days during the preceding year) The number of occasional users (less than 12 days in the preceding year) was 24 million These gures are probably subject to signi cant underreporting A sense of well-being, euphoria, loquacity, and restlessness are the familiar effects Pharmacologically, cocaine is thought to act like the tricyclic antidepressants; ie, it blocks the presynaptic reuptake of biogenic amines, thus producing vasoconstriction, hypertension, and tachycardia and predisposing to generalized tremor, myoclonus, seizures, and psychotic behavior These actions as well as its immediate mood-elevating and euphoric effects are much the same as those of dextroamphetamine (see earlier) The cocaine abuser readily develops psychologic dependence and habituation, ie, an inability to abstain from frequent compulsive use ( craving ) The manifestations of physical dependence are more subtle and dif cult to recognize Nevertheless, abstinence from cocaine following a period of chronic abuse is regularly attended by insomnia, restlessness, anorexia, depression, hyperprolactinemia, and signs of dopaminergic hypersensitivity a symptom complex that constitutes an identi able withdrawal syndrome With the increasingly widespread use of cocaine, a variety of.

The visual interface between you and your computer is known as the display In desktop computers, an external display is often called a monitor A cathode-raytube (CRT) monitor resembles a television set without the tuning or volume controls A liquid-crystal-display (LCD) is lightweight and thin This type of display is used in notebook and portable computers It has become increasingly popular for desktop computers because the technology has improved and has become somewhat less expensive

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